Thus, the analysis of genomic alterations such as the isocitrate dehydrogenase 1 and 2 (IDH1, IDH2) and the histone H3 family 3A (H3F3A), HIST1H3B, and HIST1H3C genes as well as analysis of 1p and 19q status are now integrated aspects of glioma classification. Here, IDH1 is linked to central nervous system cancer.