Thus, the analysis of genomic alterations such as the isocitrate dehydrogenase 1 and 2 (IDH1, IDH2) and the histone H3 family 3A (H3F3A), HIST1H3B, and HIST1H3C genes as well as analysis of 1p and 19q status are now integrated aspects of glioma classification. Here, H3-3A is linked to central nervous system cancer.