ALDH1A1 and Leber hereditary optic neuropathy: After the treatment of LHON patient iPSC-derived RGCs with actinomycin D, the half-life of the hsa_circ_0087207 transcript was longer than that of linear ALDH1A1 transcript, validating the higher stability of hsa_circ_0087207 than that of ALDH1A1 mRNA in patient iPSC-derived RGCs (Figure 4G).