The present study, exploring for causative association between lnc-IL7R and COPD, provides evidence that the elevated profile of circulating lnc-IL7R reflects improved pulmonary function, and is anti-correlated with effectors of pulmonary dysfunction PM2.5, PM10, and SO2, suggesting the therapeutic feasibility of lnc-IL7R as a potential actionable novel biotherapeutic/biologic for the treatment of COPD. This evidence concerns the gene IL7R and chronic obstructive pulmonary disease.