This revealed the enrichment of pathways associated to cytoskeletal signaling, remodeling of the adherent junctions, regulation of PLK1 activity at the G2/M transition and cell cycle regulation pathways at 28 d/12 °C, whereas protein processing in the endoplasmic reticulum, transcriptional misregulation in cancer and toll-like receptor signaling pathway were enriched at 28 d/18 °C. Here, PLK1 is linked to cancer.