The plasma and CSF levels of IL6 and CISD2 in 13 patients with CNS insult, including 11 head injury cases (6 TBI cases, 4 CVA cases, and 1 brain tumor case), 2 SCI cases (1 case each of AIS grade A [complete] and grade B [sensory incomplete] injuries), and 3 healthy controls were examined. Here, CISD2 is linked to brain neoplasm.