Ischemic stroke was explained by direct vascular endothelial damage or as a result of hypercoagulability (with increased D-dimer level, prolongation of the prothrombin time, disseminated intravascular coagulation) that affects the cardiovascular system especially in the context of vascular comorbidities or in the presence of cardiovascular risk factors [53,54]. Here, F2 is linked to ischemic stroke.