The innate immune system, which is the first line of defense, reacts to SARS-CoV-2 infection by increasing the production of proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and chemokines (G-CSF, macrophage inflammatory protein 1α: MIP-1α, and monocyte chemoattractant protein 1: MPC-1), and “cytokine storm” initiates self-tissue damage that generates self-tissue antigens that can mimic COVID-19 antigens [100]. The gene discussed is IL1B; the disease is COVID-19.