MAPT and dementia: Similarly, CSF t-Tau/Aβ ratio was associated with Montreal cognitive assessment (MoCA) score at two years in 390 PD patients [125], and t-Tau/Aβ42, t-Tau/α-syn, t-Tau/Aβ42+α-syn, and Aβ42/t-Tau ratios showed a significant association with the risk of progression to dementia over a 3-year follow up [126].