Moreover, a pathological hyperphosphorylated form of the Tau protein (p-Tau) may be released during neurodegenerative processes, leading to a high volume of evidence supporting that total Tau (t-Tau), p-Tau, and its ratio, may be useful in amyotrophic lateral sclerosis (ALS) and frontotemporal spectrum disorder (FTSD) differential diagnosis. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.