NFKB1 and inflammatory bowel disease: Numerous studies have revealed how important integrity of the primary DNA structure is, as mutations can affect the normal function of NFκB proteins: Polymorphisms of genes encoding NFκB subunits have been correlated with dysregulated DNA binding activity [12] across a wide spectrum of diseases, such as Huntington’s disease [13], inflammatory bowel diseases [14,15] and various cancers [16].