ESR1 and breast carcinoma: KDM6A physically interacts with ERα upon E2 treatment, demethylates H3K27me3 to facilitate the expression of C-X-C Motif Chemokine Receptor 4 (CXCR4) oncogene or the pluripotency factors NANOG, SOX2, and KLF4, which are related to breast cancer metastasis [186,187].