The opioid-induced respiratory depression (OIRD) characterized by a drastic decrease in frequency and regulation of inspiratory rhythm, originates from preBötzinger Complex (preBötC) and is mediated via, (i) μ-opioid receptor (MOR) -dependent mechanism, and (ii) μ-opioid receptor (MOR) -independent mechanism [12]. The gene discussed is OPRM1; the disease is Respiratory insufficiency due to muscle weakness.