In the wake of its recognition as a functionally relevant target in GBM, increasing experience has recently been obtained with glioma imaging directed against TSPO, including the use of PET tracers such as [18F]GE-180, [18F]DPA-714, [18F]PBR111 and [18F]VC701 [7,11,12]. This evidence concerns the gene TSPO and glioma.