Based on this knowledge, in this study we investigated the impact of pharmacological inhibition or silencing of c-Myc on the dysregulation of UPR as well as DDR, adaptive responses essential for cell survival particularly of cancers such as PEL and MM characterized by c-Myc overexpression and a constitutive high level of ER stress [21,22]. This evidence concerns the gene MYC and primary effusion lymphoma.