PARP1 and pancreatic neoplasm: For instance, and contrary to other tumors, high nuclear expression of PARP-1 has been associated with longer survival in patients with pancreatic cancer [43] whereas other authors have limited the presence of PARP-1 in acinar normal or tumoral cells but not in normal or cancer ductal cells with no significant survival differences in transgenic mice with pancreatic cancer [44,45].