GPX1 and hyperinsulinemic hypoglycemia, familial, 4: Considering NAC-induced preservation of GPx1 expression in clasmatodendritic CA1 astrocytes, our findings indicate that GPx1 upregulation in CA1 astrocytes may be an adaptive response against oxidative stress induced by GSH deficiency and may delay or prevent autophagic astroglial degeneration in the epileptic hippocampus.