TGFB1 and neoplasm: However, tumor cells also secrete some factors that serve as the immune response evasion mechanisms to avoid apoptosis; for example, the secretion of different molecules that promote regulatory T cells recruitment, polarize macrophages to an M2 phenotype [82], or promote the secretion of anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, and TGFβ, that modulate the inflammatory response, which can also be involved in tumor progression [83,84].