In this regard, some studies have reported low expression and activity of PON1 (PONase, AREase, LACase) in patients with different types cancer such as cancer blander [315], gastrointestinal cancer [308,316,317], breast cancer [308,318], prostate cancer [310,318], lung cancer [157,308,318], non-Hodgkin lymphoma [318], and central nervous system tumors [319] (Table 4). Here, PON1 is linked to lung cancer.