PON1 and coronary artery disorder: Hypo- and hyper-methylation at CpG sites along the PON1 have been evidenced in the promoter and the coding regions of this gene in populations exposed to several toxic compounds, such as heavy metals and pesticides, and in populations diagnosed with the development of different diseases, including metabolic syndrome, ischemic stroke, and coronary artery disease, among others [297,298,299].