Overall, we can conclude that supplementation with the commercial formulation Prodefen ® might be able to ameliorate hypertension by enhancing PKA, PKC and PI3K-AKT activities, thereby producing neuronal NO over-release in rat mesenteric arteries, and potentiating, in turn, the participation of perivascular nitrergic innervation. The gene discussed is PRRT2; the disease is Hypertension.