NFKB1 and Hyperglycemia: Unfortunately, the effects of Nxn mutations on the status of NXN-dependent interaction was not investigated; however, it is well-documented that NF-κB plays a key role in the pathogenesis of vascular complications of DM since persistent hyperglycemia induces oxidative stress and activates NF-κB triggering the expression of various cytokines, chemokines, among other molecules [112].