Moreover, it is known a direct action of NRF2 on proteins involved in chemoresistance such as AKR1C1-3, ABCF2, SLC40A1, as well as on the modulation of important growth factor receptors, such as c-MET, ErbB2 and EGFR regulating tumour growth [76,81]. This evidence concerns the gene EGFR and neoplasm.