SOCS3 and mastitis: Consistently, a study documented that folic acid supplementation (120 mg/500 kg body weight) for 21 days downregulated all genes associated with immune function and inflammation (PIM1, SOCS3, ATP12A, KIT,LPLNFKBIA, DUSP4, ZC3H12, ESPNL, TNFAIP3) [23] that were found to be upregulated in S. aureus-induced mastitis during the periparturient period in dairy cattle [114,115].