SOD2 and neoplasm: As such, it is surmised that acetylation status of MnSOD-K68 is a molecular switch that directs its enzymatic detoxification from its antioxidant activity (i.e., metabolic stress/protective function) as a tumor suppressor (tetrameric) or as a oncoprotein (monomeric) and, most importantly, that may promote a tumor-permissive phenotype through lineage-plasticity-like properties.