Similarly, in small-cell lung cancer (SCLC)-derived cancer stem-like cells, overexpression of MnSOD and FOXM1 mitigated the effects of genistein, decreasing stemness/lineage-plasticity-like markers and the profound migratory/invasive activity [109], whereas knockdown of MnSOD and FOXM1 enhanced the effect of genistein [109]. This evidence concerns the gene SOD2 and small cell lung carcinoma.