SOD1 and amyotrophic lateral sclerosis: Riluzole, a benzothiazole with antiglutamatergic properties that shows also antioxidant features, is the only established disease-modifying drug for ALS, although its efficacy in patients is very mild and disease stage-dependent [106,107], while it has been found unable to provide any significant benefit on lifespan and motor performances in SOD1(G93A) mice [108].