SOD1 and amyotrophic lateral sclerosis: Following the seminal linkage analysis published almost 30 years ago [12], other studies reported several ALS-associated SOD1 mutations, leading to the notion that they account for about 3% of total ALS cases (20% of fALS and 2–7% of sALS), with more than 180 mutations discovered thus far (https://alsod.ac.uk/, accessed on 13 February 2022).