The change in muscle fiber types from glycolytic to oxidative was observed in muscles of both ALS patients and mice expressing hSOD1(G93A) or (G86R) [114,126,127,130,131,132], as well as in MLC/hSOD1(G93A) muscles where an increase in lipid catabolism was also found [133]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.