ER membrane-shaping proteins, such as RTN2, ATL1, Spastin, REEP1, and ARL6IP1, have been found to cause an inherited neurological disorder termed hereditary spastic paraplegia (HSP), a disease presented by muscle spasticity, outlining the critical nature of functional ER membrane dynamics for neuron survival (Hübner and Kurth, 2014). This evidence concerns the gene RTN2 and hereditary spastic paraplegia.