Loss-of-function mutations in two RHD-containing ER-phagy receptors, FAM134B and ATL3, lead to hereditary sensory neuropathies (HSAN) caused by the decreased survival of sensory and autonomic neurons (Kornak et al., 2014; Kurth et al., 2009). Here, RETREG1 is linked to hereditary sensory and autonomic neuropathy.