Thrombosis as well as elevated circulating levels of coagulation-promoting factors such as von Willebrand factor (VWF) and pro-inflammatory cyto/chemokines including angiopoietin-2 (Ackermann et al., 2020; Dupont et al., 2021; McGonagle et al., 2021) suggest that severe COVID-19 in part should be considered an endothelial disease (Libby and Lüscher, 2020). The gene discussed is VWF; the disease is COVID-19.