While some humanized mouse models only express hACE2 in the airways, they may not recapitulate the full spectrum of pathology, while mouse models where the hACE2 gene has been inserted into the mouse Ace2 locus (Sun et al., 2020) may provide a better opportunity to assess infectability of pericytes and possible vascular consequences, as hACE2 should be expressed like mouse Ace2. It will be interesting to explore in such models whether pericytes can be infected and whether infection would be facilitated by a breakdown of vascular integrity. This evidence concerns the gene ACE2 and infection.