As obesity is reportedly associated with lower GH responses in GH provocative tests [19–22], an alternate GH cut-off for diagnosing GHD was recommended for assessing patients with a BMI ˃ 30 kg/m2, as well as in patients with a BMI of 25–30 kg/m2 and a low pretest probability [2]. This evidence concerns the gene GH1 and obesity due to melanocortin 4 receptor deficiency.