CXCL8 and Hepatic fibrosis: As IL-8, one of inflammatory cytokines, is recognized as an important mediator of inflammatory and immunological responses via inducing migratory and phagocytic activity in target cells and stimulating angiogenesis, it has been reportedly overexpressed in BA livers, and its mRNA expression was positively associated with hepatic inflammation and liver fibrosis [28], in addition to increased plasma IL-8 levels in BA patients [29].