More specifically, a number of clinical studies uncovered significant increases in systemic levels of several cytokines including inflammatory cytokines (IL-6 and IL-8) [18, 19], chemokines (IP-10 and MCP-1) [20, 21], growth factor (G-CSF) [22] and anti-inflammatory cytokines (IL-1ra and IL-10) [19, 23] in BA patients–especially those with advanced-stage. The gene discussed is CSF3; the disease is breast angiosarcoma.