Among 5 immunomodulatory cytokines, plasma levels of 2 cytokines including IL-2 and IL-15 were found to be significantly greater in BA patients than those in healthy controls (P<0.001), while plasma levels of IL-12p70 and IFN-γ in BA patients were significantly lower than those in healthy controls (P<0.001) (Fig 1). The gene discussed is IFNG; the disease is breast angiosarcoma.