Based on ROC curve analysis as displayed in Fig 6A, among 27 systemic cytokines, 4 (IL-8, IP-10, MCP-1, and PDGF) yielded an AUC of more than 0.90, thereby establishing their potential as more sensitive and specific biomarkers for differentiating BA patients from healthy controls than others. Here, CXCL8 is linked to breast angiosarcoma.