Collectively, increased systemic levels of several cytokines including inflammatory cytokines, immunomodulatory cytokines, chemokines, and anti-inflammatory cytokines and decreased systemic levels of growth factors would reflect inflammatory and immune responses related to BA development–especially alterations in plasma levels of IL-8, IP-10, MCP-1, and PDGF. This evidence concerns the gene CXCL10 and breast angiosarcoma.