The genetic associations with ischemic stroke in UKB (OR: 0.98 [95% CI 0.91, 1.06]; p = 0.66; n = 4,055) and CKB (0.94 [0.88, 1.00]; p = 0.05; n = 10,297) were also consistent with the results in MEGASTROKE (Fig 2). This evidence concerns the gene CKB and ischemic stroke.