A previous report demonstrated that Epstein-Barr virus (EBV)+ and EBV- cHL tissues can be separated from each other by a series of gene markers, such as CXCL9, CXCL10, CCL20, and other genes that involve innate immunity and antiviral responses in EBV+ tumors [16]. Here, CXCL9 is linked to classic Hodgkin lymphoma.