More cases were required for the remaining six gene loci, namely, ESR1 PvuII (rs2234693), VDR ApaI (rs7975232), VDR BsmI (rs1544410), COL1A1 1997GT (rs1107946), ESR1 G2014A (rs2228480), and ESR2 AluI (rs4986938), before a definite conclusion could be made on their correlation with osteoporosis. This evidence concerns the gene ESR2 and osteoporosis.