ESR2 and osteoporosis: Table 2 shows that in the Asian population, the cumulative sample sizes for five gene loci, namely, VDR FokI (rs2228570), TGF β1 T869C (rs1800470), insulin-like growth factor 1 (IGF1) (rs2288377), IGF1 (rs35767), and ESR2 RsaI (rs1256049), were sufficient for a conclusion of correlation with osteoporosis.