After applying DGS, we found that five gene locus polymorphisms in the Asian population were associated with osteoporosis: VDR FokI (rs2228570), IGF1 (rs2288377), IGF1 (rs35767), TGF β1 T869C (rs1800470), and ESR2 RsaI (rs1256049). The gene discussed is ESR2; the disease is osteoporosis.