Table 1 shows that in the Caucasian population, the cumulative sample sizes for eight gene loci, namely, vitamin D receptor (VDR) ApaI (rs7975232), VDR BsmI (rs1544410), interleukin 6 (IL6) G174C (rs1800795), collagen type I alpha 1 (COL1A1) 1245GT (rs1800012), estrogen receptor 1 (ESR1) PvuII (rs2234693), ESR1 XbaI (rs9340799), estrogen receptor 2 (ESR2) RsaI (rs1256049), and osteoprotegerin (OPG) T245G (rs3134069), were sufficient for a conclusion of noncorrelation with osteoporosis. Here, ESR2 is linked to osteoporosis.