More cases were required for the other nine gene loci, namely, VDR FokI (rs2228570), VDR TaqI (rs731236), transforming growth factor-β1 (TGF β1) T869C (rs1800470), low-density lipoprotein receptor-related proteins 5 (LRP5) (rs3736228), ESR1 G2014A (rs2228480), ESR2 AluI (rs4986938), OPG T950C (rs2073617), OPG A163G (rs3102735), and OPG G1181C (rs2073618), before a definite conclusion could be made on their correlation with osteoporosis. This evidence concerns the gene TNFRSF11B and osteoporosis.