In this study, when the DGS was used for stratification by ethnicity, it became evident that VDR FokI was not correlated with osteoporosis in Caucasians, and TSA results showed that more cases were required to obtain a definite conclusion; conversely, the DGS showed that VDR FokI significantly correlated with osteoporosis in Asians. Here, VDR is linked to osteoporosis.