SENP1 was reported to play an important role in regulating AR‐dependent transcription and hypoxia signalling by removing SUMO isoforms from AR, and the expression of SENP1 directly correlates with the aggressiveness and recurrence of prostate cancer by regulating two critical bone remodelling proteins, MMP2 and MMP9.35 Here, MMP2 is linked to Familial prostate cancer.