As controlling the expression level, intracellular localisation and transcriptional activity of TFE3 fusion protein are critical steps for tumour progression of Xp11.2 tRCC, we first investigated the effect of AR on the expression level of wild‐type TFE3 and TFE3 fusions. This evidence concerns the gene TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.