AR and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: In this study, we aimed to explore the relevance of androgen/AR to the progression of Xp11.2 tRCC and further reveal the detailed mechanism by which AR affects the progression of Xp11.2 tRCC and then explore interventions for Xp11.2 tRCC by targeting AR.