In turn, the transcription of SENP1 is significantly elevated with chronic androgen exposure in the androgen‐sensitive human prostate cancer cell line, indicating the feedback mechanism between SENP1 and AR,36 which might explain the overexpression of SENP1 both in prostate cancer tissue samples and precancerous prostate intraepithelial neoplasia lesions.37 Here, AR is linked to prostate intraepithelial neoplasia.