RNPC3 and viral infectious disease: Several protocols using AAV vectors, together with Cas9 or Cas12a, were developed to introduce CARs or TCRs into the TRAC locus of T cells, often demonstrating ≥50% transgene integration through combined Cas9-RNP electroporation and virus infection (Mansilla-Soto et al., 2022; Zhang et al., 2021).