Like us, many investigators found TLR to be statistically significantly higher in tumors with negative prognostic factors, such as high grade and microvascular invasion (Bailly et al. 2016), high preoperative AFP level, Milan out, University of California, San Francisco (UCSF) out, large tumor size, major vessel invasion, and serosal invasion (Lee et al. 2013; Ye et al. 2017). Here, AFP is linked to neoplasm.