BRCA1 and cancer: The main goals of this study were to evaluate our cancer registry to assess the prevalence of germline variants in cancer-predisposing genes besides BRCA1/2 in Granada’s high-risk HBOC population and to follow-up patients who had a pathogenic (class V) or likely pathogenic (class IV) variant to assess clinical impact regarding prophylactic surgery (either mastectomy, oophorectomy, or both) and periodic follow-up.