The IHC staining of the tumor of mice showed that the expression of CDK19 protein was significantly increased in the LV-miR-ctrl and OE-CDK19 co-transfected group, while the expression of CDK19 protein was reversed in the LV-miR-222-3p and CDK19 co-transfected group (Fig. 3G). This evidence concerns the gene CDK19 and neoplasm.