GC and obesity due to melanocortin 4 receptor deficiency: Additionally, it could also be ascribed to circulating vitamin D binding protein (VDBP) because VDBP has a greater binding affinity for 25(OH)D compared to 1,25(OH)2D39, 40 and levels of VDBP are reported to be reduced in acute inflammation, suggesting that, in obesity, which is characterised by chronic low‐grade inflammation, circulating VDBP levels may be reduced.41, 42