The warming Yang method in TCM is considered an important prophylactic and therapeutic treatment for breast cancer.[21] The representative formula of Yanghe decoction can inhibit proliferation, reduce metastasis and induce the apoptosis of breast cancer cells, and its mechanism may be related to its inhibition of the activation of PI3K/Akt/NF-κB signaling pathway.[22–26]. Here, AKT1 is linked to breast cancer.