A previous study revealed that Yanghe decoction inhibited the growth of MDA-MB-231 cell lines, downregulated NF-κB protein expression and inhibited IL-8 secretion.[24] Our team also found the simplified formula “Yanghe Tongluo Drink” (Patent Application Number: 201911006384.7) had remarkable efficacy on plasma cell mastitis after minimally invasive surgery. The gene discussed is NFKB1; the disease is mastitis.