CASP3 and early-onset autosomal dominant Alzheimer disease: Specifically, caspase-3 activation in astrocytes is associated with cytoskeletal remodeling in a kainic acid–induced neurodegeneration model (45), reactive astrocytes following excitotoxic NMDA-induced neurodegeneration (47), and GFAP cleavage in an Alzheimer’s disease model (44).