FMR1 and congenital hypogonadotropic hypogonadism: Specifically, in 2017, Stuppia and Gatta recommended karyotyping and only FMR1 assessment (Stuppia & Gatta 2017), while in 2019, Toth and colleagues recommended karyotyping, FMR1 and CYP21A2 testing, as well as congenital hypogonadotropic hypogonadism gene panel testing (Toth et al. 2019).