A low inter‐follicular density of CD8+FOXP3+ cells is associated with increased risk of relapse independent of follicular lymphoma international prognostic index (FLIPI) (p = 0.038, Hazard ratio (HR) = 0.42 [0.19, 0.95], but not independent of co‐localization of CD8+FOXP3+ with CD4+CD8+ cells (p = 0.43). Here, CD8A is linked to follicular lymphoma.