While there is no doubt that there is an association between SUs (especially the older agents like glibenclamide) and insulin treatment and hypoglycemia, the high rates of poor glycemic control in type 2 diabetes patients and relatively low hypoglycemic events among patients taking SUs suggest that there is room for optimizing glycemic control using these cheap, readily available and effective agents, despite the specific challenges of food insecurity and lack of glycemic monitoring in many LMIC populations. The gene discussed is INS; the disease is Hypoglycemia.