When adjusting to HbA1c of 53 mmol/mol (7%), an internationally recognized target for glycemic control, estimated minutes in hypoglycemia (per week) were 137.2 (95% CI 49.6 to 224.7), 290.9 (168.8 to 413.0) and 751.9 (433.9 to 1070.0) with metformin, SU and insulin, respectively (online supplemental material 3). Here, INS is linked to Hypoglycemia.