INS and Hypoglycemia: In unadjusted analysis, the mean number of minutes <3 mmol/L per week for SU and metformin treatment did not substantially differ (duration ratio SU vs metformin 1.4 (95% CI 0.69 to 2.91), p=0.35), but duration in hypoglycemia substantially higher with insulin than metformin (duration ratio 2.5 (95% CI 1.3 to 5.0), p=0.009).