Despite the fact that more than 1/5 participants in the pre-stable and post-increase group began to use oral drugs combined with insulin to control blood glucose at baseline, they had HbA1c deterioration in the course of T2DM progress, indicating that the deterioration of HbA1c control is a potential risk factor for chronic comorbidities and death in T2DM patients. This evidence concerns the gene INS and type 2 diabetes mellitus.