Others showed that the C-terminal truncated X protein (Ct-HBx) produced by the preferential clustering pattern at the 3′-end of the HBV genome X gene downregulates TXNIP by activating transcriptional repressor nuclear factor of activated T cells 2 (NFACT2), reprogramming glucose metabolism to initiate HCC [109]. This evidence concerns the gene TXNIP and hepatocellular carcinoma.