SIRT1 and Hyperglycemia: The plant extract Cissus quadrangularis has been reported to improve DN-related outcomes owing to its ability to reverse hyperglycemia-induced SIRT1 downregulation [24], while Camellia sinensis L. can target the SIRT1/AMPK signaling axis to alleviate inflammation and reduce the severity of renal injury in diabetic model mice [25].