Trehalose significantly increased cell death (P < 0.001 vs. UVB group), exhibiting a clearance effect on tumor cells, and TIMP3 and ATG9A siRNA inhibited trehalose-induced cell death under UVB exposure conditions (P < 0.01 vs. UVB + TRE group) (Figure 5(f)). This evidence concerns the gene ATG9A and neoplasm.