TNF and rheumatoid arthritis: Profitable attributes of curcumin have been shown to lay a heavy impact on the functionality of RA FLS by reducing their survivability and hence the number of overproliferating cells [19], decreasing expression of IL-1β, TNF-α, and COX-2 proteins and diminishing production of tissue destroying metalloproteinases (MMP-1, MMP-3, and MMP-13) [16, 20, 21].