IL6 and systemic lupus erythematosus: Cytokines such as IL-6, IL-23, IL-17, and Tregs that take a part in the SLE pathogenesis, Nigella sativa L. have been proven to modulate these cytokines and eliminate organ damage (including renal) in various diseases but the information about the effect on SLE is limited (Tackey et al., 2004; Dolff et al., 2011; Crispín et al., 2010; Rönnblom and Elkon, 2010).