Lupi-Herrera et al. observed a higher risk of arterial and venous thromboembolic disease and described an increase in massive and submassive pulmonary embolism and acute myocardial ischemia in patients with MTHFR A1298C (p = 0.017) and increased homocysteine levels [33]. The gene discussed is MTHFR; the disease is pulmonary embolism.