The αvβ3 receptor also plays a role in tumor progression and metastasis formation: by controlling the actin cytoskeleton (Havaki et al., 2007); by supporting tumor cell binding to, and transmigration across activated endothelia (Saalbach et al., 2005); by synergizing with VEGF-dependent pathways to promote angiogenesis (Mahabeleshwar et al., 2007); and by sustaining the activation of the Src kinase (Huveneers et al., 2007). This evidence concerns the gene VEGFA and neoplasm.