LRP2 and holoprosencephaly: LRP2 deletions were also associated with mild forms of holoprosencephaly (Rosenfeld et al., 2010), which were mirrored by the presence of an enlarged LV in the brain of LRP2-deficient mice, although the ventricular system and the ependymal layer did not show obvious alterations (Gajera et al., 2010).