The IRS1 rs1801278 (C > T) variant has been related to GDM in meta-analyses (Zhang Y. et al., 2014; Wu et al., 2016), similarly to the rs7578326 (A > G) polymorphism (Voight et al., 2010; Zheng et al., 2013; Zhao et al., 2017). Here, IRS1 is linked to gestational diabetes.