BAX and autoimmune thrombocytopenic purpura: Accordingly, the expressions of proapoptotic proteins Bak and Bax were increased, and the ratios of Bak/Bcl-2 and Bax/Bcl-2 were upregulated in the ITP patient samples, as shown by Western blotting analysis of platelet lysate (Figures 5E, Supplementary Table S2).