Accordingly, the expressions of proapoptotic proteins Bak and Bax were increased, and the ratios of Bak/Bcl-2 and Bax/Bcl-2 were upregulated in the ITP patient samples, as shown by Western blotting analysis of platelet lysate (Figures 5E, Supplementary Table S2). This evidence concerns the gene BAK1 and autoimmune thrombocytopenic purpura.